Description
Master’s Degree in BIOCHEMISTRY (MSCBCH)
Course code: MBC-009
Course title: CLINICAL BIOCHEMISTRY
(Valid from 1st July, 2025 to 31stDecember, 2026)
Note: Attempt all questions.The marks for each question are indicated against it. For any question worth 2 marks, the word limit is 50 words, for 5 marks question it is 100 words; and for 10 marks it is 250-300 words. PART-(A)Maximum marks: 50
1 What are different types of autoanalyzers? How are they advantageous in a clinical laboratory?
2 (a) Explain composition of blood. How is blood sample used to distinguish a normal person from the one with anemia and polycythemia?
(b) Enlist five precautions that should be observed while handling infected samples in a clinical laboratory.
3 (a) Explain the clinical significance of alanine aminotransferase and discuss the principle of its assay.
(b)How does our body maintain electroneutrality with difference in composition of different compartments?
4 (a) Write clinical significance of the following:
(i) White blood cells (ii) Clotting time (iii) ESR (iv) Sodium (v) Chloride
(b) Write the genetic cause of the following:
(i) Thelessemia and (iii) Non-Ketotic Hyperglycinemia
5 Write short notes on pentosuria and dyslipidemia
PART-(B) Maximum marks:
1 Describe the pathology, symptoms and diagnosis of gout.
2 (a) Write a note on the clinical significance of the following: Gamma GlutamylTransferase (GGT) and Ornithine Transcarbamylase deficiency
(b) Discuss the classification and clinical findings of jaundice.
3 (i) Discuss the symptoms and diagnostic parameters for acute myocardial infarction.
(ii) Explain the clinical relevance of Creatinine clearance test (CCT).
4Write short notes on Grave’s disease and Hashimoto thyroiditis.
5 (a) Explain Ames test and discuss its importance.
(b) Explain the terms: (i) Warburg effect, (ii) Correlation between obesity and BMI
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