BBCS-185 EM 2026 SOLVED ASSIGNMENT

Description

ASSIGNMENT BIOINFORMATICS

Course Code: BBCS-185

Assignment Code: BBCS-185/TMA/2026

Maximum Marks: 100 Answer all the questions given below.

1. Explain the scope of bioinformatics and describe its role in genomics, proteomics, and systems biology.
2. Classify biological databases into primary, secondary, and composite databases with suitable examples.
3. Define similarity, identity, and homology in sequence analysis and explain their significance in sequence alignment.
4. Describe the principles of pairwise and multiple sequence alignment and differentiate between global and local alignment.
5. Explain the structure and importance of amino acid substitution matrices such as PAM and BLOSUM in sequence analysis.
6. Describe how bioinformatics tools and databases are used in computer-aided drug design, highlighting structure-based and ligand-based approaches.
7. Explain the steps involved in retrieving a gene or protein sequence from NCBI and analyzing it using BLAST.
8. Discuss the use of metabolic pathway databases such as KEGG and MetaCyc in understanding cellular metabolism and disease pathways
9. Explain how multiple sequence alignment using CLUSTALW can be applied to study evolutionary relationships among proteins
10. Describe the practical workflow for downloading a protein structure from the PDB and visualizing it using PyMol, including the role of molecular file formats.-