Description
Assignment
TOXICOLOGY
Course Code: MBCE-016
Assignment code: MBCE-016/TMA/2025-26
Note: Attempt all questions. The marks for each question are indicated against it.
For any question worth 2 marks, the word limit is 50 words, for 5 marks question it is 100 words; and for 10 marks it is 250-300 words.
PART-(A) Maximum marks: 50
| 1 (a)
(b) |
Write the scope of modern toxicology and environmental toxicology.
Differentiate between the following: i) Reversible and irreversible toxicity ii) Local and systemic toxicity |
5
5 |
| 2 (a) | Enlist various cosmetic ingredients and their possible toxic effects on humans and experimental animals. | 5 |
| (b) | What are TLVs? Mention their significance in occupational toxicology. | 5 |
| 3 (a)
(b) |
Explain the difference between subchronic, chronic, subacute and acute toxicity with example.
Explain the dose-response relationship. |
5
5
|
| 4 (a) | Which are the three common routes through which humans are exposed to the toxicants. Discuss any one in detail. | 5 |
| (b) | Write short note on bioavailability of toxicants. | 5 |
| 5 | Enlist different types of phase I reactions and discuss the role of cytochrome P450 in toxicant metabolism. | 10 |
PART-(B) Maximum marks: 50
| 6 | How does polymorphism in xenobiotic metabolizing enzymes result in variation in response to the toxicants? | 10 |
| 7
|
Explain the following:
(a) Reasons of selective organs toxicity of toxicants (b) Systemic lung toxicants |
10 |
| 8 | Discuss the mechanism of hepatotoxicity caused by the following toxicants:
(i) Carbon tetrachloride (ii) Paracetamol |
10 |
| 9 (a) | Which factors make kidney susceptible to nephrotoxicity? How does cyclosporin cause injury to kidneys? | 5 |
| (b) | Explain the mechanism of neurotoxicity by methylmercury and cardiovascular injury by cardiac glycosides. | 5 |
| 10 (a) | Give an example of the accident that led to radioactive spill. Enlist the toxic effects of exposure to radioactivity. | 5 |
| (b) | Explain the terms: (i) bioconcentration (ii) Biomagnification | 5 |
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