Description
M.SC. (HONOURS) (BIOCHEMISTRY) (MSCBCH)
Term-End Examination December, 2025
MBC-008 : GENETICS AND EVOLUTIONARY BIOLOGY
Time : 3 Hours Maximum
Marks : 100
Note : Answer any five questions. All questions carry equal marks.
1.(a) Discuss recombination and explain the various types of recombination processes occurring in nature.
(b) Describe the role and importance of rII locus of T4 phage and the concept of cistron
2.(a) Explain the unique features and characteristics of Drosophila and C. elegans that make them model organisms. (b) Describe the laws of probability for predicting genetic outcomes.
3.(a) What are the different types of allelic variation ? Describe any two of them.
(b) Differentiate the following :
(i) X-linked recessive and X-linked dominant disorders
(ii) Linked and Imprinted genes
4.(a) Describe gametogenesis and explain oogenesis in detail.
(b) Explain early embryonic stages in the development of Drosophila.
5.(a) Discuss pedigree analysis. Enlist any eight standard symbols used in pedigree analysis. 1
b) Describe mechanisms underlying chromosomal aberrations. Explain variations in chromosome number.
6.(a) What are homologous sequences ? Classify them and explain their evolutionary relationship.
b) Explain the different types of human polymorphisms.
7.(a) Describe Luria Delbruck fluctuation test to support spontaneous mutation.
(b) What are adult stem cells ? Explain its different types.
8.(a) Write a detailed note on in-vitro fertilisation (IVF).
(b) Explain chromosomal sex determina tion mechanisms.
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