Description
ASSIGNMENT
Metabolism of carbohydrates and lipids
Core Course in Biochemistry
Course Code: BBCCT-109
Assignment code: BBCCT-109/TMA/2024
Maximum marks: 100
Note: Attempt all questions. The marks for each question are indicated against it.
Write the answers in your own words; do not copy from the course material.
PART-(A) Marks: 50
1. Differentiate the terms and give suitable example of each: (5X2= 10)
(a) Obligate and facultative anaerobes
(b) Oxidative and substrate level phosphorylation
2. (a) Name two coenzymes derived from the vitamin riboflavin. Write one reaction indicating their role.
(2+3)
(b) Explain the regulation of glycolysis pathway. (5)
3. (a) Describe the role of pyruvate dehydrogenase enzyme complex in acetyl CoA synthesis. (5)
(b) What is pentose phosphate pathway and its importance? (5)
4. (a) Which factors govern the reciprocal regulation of glycolysis and gluconeogenesis and why is it
important? (5)
(b) Demonstrate the role of reversible covalent modification of enzymes in glycogen metabolism. (5)
5. (a) Draw Calvin cycle and explain carbon fixation by RuBisCo in plants. (5)
(b) What are the clinical implications if blood glucose homeostasis is not maintained? (5)
PART- (B) Marks: 50
6. (a) With the help of a neat diagram, explain the stages in digestion, absorption and transport of dietary
fats. (5)
(b) What is the product of last reaction in β- oxidation of a saturated fatty acid with odd number of
carbon atoms? Explain its fate in animals and plants. (1+4)
7. (a) Write short notes on Refsum’s disease and ketosis. (5)
(b) Write the role of acetyl CoA carboxylase in fatty acid synthesis.
(5)
8. (a) Name the key regulatory enzyme of de novo cholesterol biosynthesis. How does it exert the
regulation? (5)
(b) Calculate the energy cost of synthesis of palmitic acid. (5)
9. (a) Explain the synthesis of triacylglycerols from dihydroxyacetone as precursor. (5)
(b) Which type of lipids use ceramide as backbone? Give a general overview of the pathway for
synthesis of ceramide. (1+4)
10. (a) Write different possible fates of glucose in liver. (5)
(b) Explain the role of any two hormone signals which regulate fat metabolism. (5)
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